Best Weight Loss Supplements for Women in 2025

One of the most popular New Year’s resolutions is weight loss. Sustainable weight loss starts with healthy eating, regular exercise, stress management, and an overall balanced lifestyle. But the right dietary supplements can also play a big role in boosting your progress.

In this article, we’ll cover the best weight loss supplements for women in 2025, including thermogenic supplements, appetite suppressants, metabolic boosters, hormone-supporting supplements, omega-3 supplements, probiotics, and fiber supplements.

With the guidance of your healthcare provider, these weight loss supplements for women can help you reduce body fat, lose weight, and build lean muscle mass—helping you achieve the health and vitality you desire in the new year.

Thermogenic Supplements for Metabolism and Fat Burning

Thermogenic supplements are among the best weight loss supplements for women. They help to improve your body’s natural ability to burn fat and calories (1). They do this by increasing thermogenesis, the process of heat production in the body. By stimulating the central nervous system and raising energy expenditure, thermogenics may aid your body burn more calories even at rest. They may support fat oxidation, converting stored fat into energy, which can also support weight loss.

Top Thermogenic Supplements

The most popular ingredients of thermogenic supplements include:

Caffeine: Caffeine is a natural stimulant commonly found in coffee, tea, chocolate, and energy drinks. It can boost energy and alertness by blocking adenosine, a neurotransmitter that promotes sleep. According to a 2019 study published in Critical Reviews In Food Science And Nutrition, caffeine may help weight loss (2).
Capsaicin: Capsaicin is a natural compound found in chili peppers that gives them their spicy heat. It may improve metabolism and decrease appetite by stimulating thermogenesis. According to a 2017 research published in Bioscience Reports, it may help to fight obesity (3).
Green Tea Extract: Green tea extract is a concentrated form of green tea leaves. It is high in antioxidants, including catechins, which may be beneficial for boosting metabolism and supporting weight loss. According to a 2020 review published in Nutrients, green tea extract can be effective for weight loss support (4).

Appetite Suppressants

Appetite suppressants are substances designed to help reduce hunger and control cravings, making it easier to stick to a calorie-controlled diet. They can work in various ways, such as altering brain signals related to hunger, stabilizing blood sugar levels, or creating a feeling of fullness.

They are often recommended as some of the best weight loss supplements for women because they address one of the biggest challenges in weight management: controlling hunger and cravings.

How Do Appetite Suppressants Work?

Appetite suppressants work by targeting the body’s hunger and fullness signals, helping to reduce cravings and prevent overeating. They influence hunger hormones, ghrelin, and leptin, which regulate appetite and satiety. They help to increase the feeling of fullness, minimize overeating and snacking, and help you fight emotional eating as well. They can be helpful when used alongside a nutrient-dense diet, an exercise plan, and a healthy lifestyle.

Common Appetite Suppressant Ingredients

We recommend using natural appetite suppressants that help to curb hunger naturally.

Glucomannan: Glucomannan is a great option for a dietary supplement. It is a fiber derived from the Konjac root. When mixed with water, glucomannan may help to expand your stomach, which may increase fullness and reduce hunger. According to a 2020 review published in Obesity Medicine, glucomannan may help weight reduction in overweight and obese individuals (5).
5-HTP (5-Hydroxytryptophan): 5-HTP is a natural compound derived from the amino acid tryptophan. By increasing your serotonin levels, 5-HTP may help to improve your mood. This can reduce cravings—especially for sugary and heavy comfort foods, emotional eating, and overeating—and thus affect body weight. According to a 2011 study published in Eating and Weight Disorders, taking 5-HTP for 4 weeks only helped with fullness and reduced food intake (6).
Fenugreek: Fenugreek is an herb with edible seeds. It’s a popular food and supplement with various benefits, including weight loss due to its fiber content. According to a 2015 study published in Clinical Nutrition Research, it may help to increase fullness and reduce appetite (7).
Psyllium: Psyllium is a soluble plant-based fiber. It makes a gel-like substance in the stomach, which can lead to a feeling of fullness and reduced appetite. According to a 2023 review published in the American Association of Nurse Practitioners, it may be effective for weight loss (8).
Green Tea Extract: Green tea offers the benefits of the antioxidant catechin and epigallocatechin-3-gallate (EGCG). It may help with reduced appetite, increased fullness, better metabolism, and increased gut health. According to a 2020 review published in Nutrients, between 100 and 460 mg a day can be effective for weight loss support (4).
Alpha Lipoic Acid (ALA): ALA is an antioxidant fatty acid. It supports your body in creating energy from sugars. It helps to break down fat, reduce appetite, and support blood sugar levels. According to a 2017 review published in Obesity Reviews, ALA may support short-term weight loss (9).

Metabolism Boosters

Metabolism boosters are substances or supplements designed to increase the rate at which your body burns calories and converts food into energy. By enhancing metabolic processes, they can help support weight loss efforts by encouraging more efficient energy expenditure, even while at rest. When used in combination with a healthy diet and regular exercise, they can be helpful in losing weight.

Supplements for Metabolic Function

Supplements for metabolic function work by supporting the body’s ability to convert food into energy efficiently and maintain a balanced metabolism. They often include nutrients like B vitamins and CoQ10 to enhance energy production, ingredients like green tea extract or L-carnitine to promote fat oxidation, and compounds that help regulate hormones involved in metabolism, such as insulin or cortisol. By targeting these key processes, these supplements can help improve energy levels, support weight management, and optimize overall metabolic health.

Key Metabolic Booster Nutrients

Some of the top nutrients that may improve your metabolism include:

Vitamin B Complex: B vitamins, including vitamin B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6, B9 (folate), B7 (biotin), and B12 play a critical role in your metabolic health and help to metabolize fat, protein, and carbohydrates (10, 11, 12). According to a 2018 research published in Current Medical Sciences, B vitamins may help weight loss by supporting metabolism (13).
Chromium: Chromium is a trace mineral. It helps regulate blood sugar levels by improving the action of insulin, supporting energy metabolism, and decreasing cravings. According to a 2003 paper published in the International Journal of Obesity, chromium may help to support weight loss (14). However, it’s only a piece of the puzzle, nutrition and exercise are non-negotiables.
L-carnitine: L-carnitine is an amino acid derivative that helps transport fatty acids into the mitochondria, where they are converted into energy. According to a 2020 review published in Clinical Nutrition ESPEN, l-carnitine may help with fat loss and body composition in overweight individuals (15).
Vitamin D: Vitamin D is a fat-soluble vitamin that supports calcium absorption, bone health, immune function, and overall well-being. According to a 2023 research published in BMC Endocrine Disorders, vitamin D may help to manage blood sugar balance and reduce insulin resistance (16). This may also help to reduce cravings for sugary foods and overeating due to blood sugar imbalances.

Hormonal Balance and Weight Loss

When it comes to effective weight loss supplements for women, hormone-balancing options are often among the most impactful. Hormones like insulin, cortisol, estrogen, and thyroid hormones play a significant role in regulating metabolism, appetite, fat storage, and cravings. When these hormones are out of balance, it can lead to weight gain, difficulty losing weight, or even increased fat storage despite healthy lifestyle choices.

Hormone-Balancing Supplements for Weight Loss

Hormone-balancing supplements help to improve hormonal and endocrine balance by reducing stress, improving insulin sensitivity, improving thyroid function, supporting metabolism, reducing estrogen dominance, and addressing other hormonal dysfunctions that may impact weight loss.

Top Hormone-Balancing Supplements

Diindolylmethane (DIM): DIM is a natural compound found in cruciferous vegetables that promotes hormone balance by supporting healthy estrogen metabolism and decreasing estrogen dominance. According to a 2017 research published in Molecular Nutrition and Food Research, DIM may help to reduce adipogenesis and obesity from a high-fat diet (17).
Adaptogens: Adaptogens are natural substances that help the body adapt to stress and maintain balance. Adaptogens include ashwagandha, maca, and ginseng. Since stress is a major contributing factor to weight gain and obesity, by reducing stress-induced cortisol spikes, adaptogens may help. According to a 2016 study published in the Journal of Evidence-Based Complementary and Alternative Medicine, ashwagandha may help with weight loss in people under chronic stress (18). According to a 2006 animal study published in the International Journal of Biomedical Sciences, maca may help with weight loss in women both in pre- and postmenopause (19). According to a 2017 study published in the Journal of Ginseng Research, ginseng may help to reduce appetite and aid weight loss (20).

Omega-3 Supplements for Weight Loss

Omega-3 fatty acids are another top recommendation when it comes to weight loss supplements for women. These essential fats not only support overall health but also play a crucial role in fat-burning and metabolic efficiency.

Omega-3 Supplements for Fat-Burning and Inflammation

Omega-3 fatty acids are anti-inflammatory fatty acids that may help to reduce chronic inflammation and improve fat-burning processes (21, 22). This can improve metabolic efficiency in the body. Omega-3 fatty acids, particularly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), may help to improve insulin sensitivity, which helps the body to use glucose more effectively and store less fat (23).

According to a 2013 study published in the European Journal of Clinical Nutrition, omega-3s may help to regulate leptin, the hunger hormone, which helps to promote fullness and reduce caloric intake (24). According to a 2020 study published in Nutrition Hospitalaria, omega-3 fatty acids may help weight loss in overweight individuals on a weight-loss diet (25).

Best Omega-3 Supplements

For omega-3 supplementation for weight management, we recommend fish oil supplements, or if you are looking for a vegan source, algae oil supplements with EPA and DHA. These supplements with EPA and DHA are superior to flaxseed, chia seed, and hemp seed supplements which contain ALA (alpha-linolenic acid) instead of EPA and DHA. Though your body can convert ALA to EPA and DHA, it is at a low rate. Fish and algae oil supplements with EPA and DHA are more efficient and bioavailable.

Fish Oil: Fish oil supplements are the most common supplements for omega-3 fatty acids. They contain high amounts of EPA and DHA. According to a 2010 study published in the Journal of the International Society of Sports Nutrition, fish oil may help to improve body composition, metabolism, and weight (26).
Algae Oil: Algae oil supplements are a vegan and vegetarian option for omega-3 supplementation. Some algae oil supplements only contain DHA. Look for a brand that contains both EPA and DHA at higher levels. Since algae oil tends to have lower levels of omega-3s than fish oil supplements, you may need to take more capsules per day or consider using fish oil supplements instead. According to a 2016 article published in The Journal of Biomedical Research, algae oil supplements may be a good alternative to fish oil for weight loss (27).

Probiotics for Gut Health and Weight Loss

Probiotics are beneficial bacteria that support a healthy gut microbiome, which plays a critical role in digestion, metabolism, and overall health. Recent research suggests that an imbalanced gut microbiome can contribute to weight gain, inflammation, and metabolic issues, making probiotics an important tool for those looking to lose weight.

Gut Health and Weight Management

Gut microbiome imbalances due to a poor diet, unhealthy lifestyle choices, chronic stress, medication use, and environmental toxins can increase chronic inflammation, gut inflammation, digestion problems, and weight gain. It can make weight loss and weight management more difficult (28, 29, 30).

Using probiotic supplements can help to restore gut microbiome balance, improve digestion, improve nutrient absorption, and support metabolic processes. It can help to regulate your appetite and support your weight loss goals.

Specific Probiotic Strains for Fat Loss

We recommend using a high-quality probiotic supplement for weight loss daily. Look for probiotics with certain probiotic strains that support fat loss, such as Lactobacillus and Bifidobacterium.

Lactobacillus gasseri: Lactobacillus gasseri may help to reduce belly fat and body weight. According to a 2013 study published in the Korean Journal of Family Medicine, it may be beneficial for overweight and obese individuals (31).
Bifidobacterium breve: Bifidobacterium breve supports improved fat metabolism and reduced fat storage. According to a 2022 study published in Nutrients, it may help to decrease body weight, as well as, waist and hip circumference (32). Both strains may help to reduce inflammation, improve fat breakdown, regulate appetite hormones like leptin and ghrelin, and support weight loss.

Fiber Supplements

Finally, the last one of the best weight loss supplements for women we recommend is fiber. Fiber and fiber supplements can tremendously support your weight loss goals (33). Soluble fiber absorbs water and forms a gel-like substance in the gut. This slows digestion, which can improve satiety and feel full longer. It may help to reduce your calorie intake and aid weight loss helping you feel full for longer and reducing overall calorie intake (34).

Insoluble fiber, on the other hand, adds bulk to your stool stool. It can support regular bowel movements and prevent constipation, which can also support you in maintaining a healthy weight (35, 36). Prebiotic fiber also helps to support probiotics, or healthy gut bacteria for better digestion (37). Fiber can also help to stabilize blood sugar levels, reduce hunger spikes, and balance appetite to support weight management (38).

Popular Fiber Supplement Options

A nutrient-dense diet rich in fiber-rich greens, vegetables, sprouts, herbs, spices, fruit, nuts, and seeds should be your number one way to increase fiber and support weight loss. However, fiber supplements can help. You can incorporate them into your meals and beverages for practical weight loss support. Popular fiber supplements include psyllium husk and inulin.

Psyllium Husk: Psyllium husk is a soluble fiber. It is commonly used for improving bowel regularity, reducing bloating, and increasing satiety. According to a 2023 study published in the Journal of the American Association of Nurse Practitioners, psyllium husk used before meals can help with weight loss and reduce waist circumference in overweight and obese individuals (39).
Inulin: Inulin, a prebiotic fiber. It supports digestive health by feeding beneficial gut bacteria, stabilizing your blood sugar levels, and supporting metabolism. According to a 2022 study published in Scientific Reports, inulin may aid weight loss and improve body composition (40).

Try These Best Weight Loss Supplements For Women To Kick-Start Your Health Goals

If losing weight is among your goals for the new year, pairing a weight loss supplement with healthy habits and a balanced diet may help you achieve your goals. Following a nutrient-dense diet, moving your body regularly, reducing stress, sleeping plenty, and correcting underlying health issues, including gut microbiome imbalances, hormonal imbalances, and chronic inflammation are key for sustainable weight loss and weight management.

If you choose to add any prescription medications or weight loss supplements into the mix, it’s important to consult a healthcare provider before starting anything new or changing your dose. Some supplements may interact with certain medications or exacerbate certain health issues such as high blood pressure, so it’s important that you choose the right ones for your body.

A functional, integrative, or naturopathic practitioner can also guide you on what supplements may be right for your body and how to lose weight naturally, in a sustainable manner. Our practitioners can spot underlying health issues and offer natural, personalized treatment strategies.

If you want to lose weight and want the help of the best weight loss supplements for women, we can help. We invite you to set up an appointment with us here.