EP 10: What Is Gut Health?

In this week’s episode, Dr. Agolli chats with Dr. Burdette and they dive deep into your gut health.

What is a leaky gut?
How does your gut impact the rest of your body?
How can you improve your gut health?

“Leaky gut” is a term used to describe increased intestinal permeability. The lining of the intestines is made up of cells that are tightly packed together, forming tight junctions. These tight junctions act as a barrier, preventing unwanted substances from passing through into the bloodstream.

Zonulin is a protein that regulates the permeability of these tight junctions. When zonulin levels rise, the tight junctions between cells open up, allowing substances to pass through into the bloodstream. This can lead to an immune response and inflammation in the gut and throughout the body.

The microbiome, or the community of microorganisms that live in our gut, can impact leaky gut. An imbalance in the microbiome, known as dysbiosis, can contribute to increased intestinal permeability.

Zonulin levels can rise in response to several triggers. One of the most powerful triggers for zonulin release is the presence of gliadin, a glycoprotein found in gluten. When gliadin is present in the small intestine, it can stimulate the release of zonulin, leading to increased intestinal permeability.

Other factors that can contribute to increased zonulin levels and leaky gut include an overgrowth of harmful bacteria or yeast in the intestine, small intestinal bacterial overgrowth (SIBO), fungal dysbiosis or candida overgrowth, and parasite infections.

Leaky gut can cause a wide range of symptoms, as it can affect many different systems in the body. Some common symptoms of leaky gut include:

Digestive problems such as bloating, gas, diarrhea or constipation
Food sensitivities or allergies
Chronic fatigue or low energy
Skin problems such as acne, eczema or rosacea
Joint pain or stiffness
Mood issues such as anxiety or depression
Nutrient deficiencies

A test that may be used to assess leaky gut is the zonulin test. This involves measuring levels of zonulin in the blood or stool. High levels of zonulin can indicate increased intestinal permeability.

There are several factors that can contribute to the development of leaky gut. Some common causes include:

Poor diet: A diet high in processed foods, sugar, and unhealthy fats can contribute to inflammation and damage to the gut lining.
Chronic stress: Chronic stress can weaken the immune system and contribute to inflammation in the gut.
Imbalance in gut bacteria: An imbalance in the gut microbiome, known as dysbiosis, can contribute to increased intestinal permeability.
Medications: Certain medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and antibiotics, can damage the gut lining and contribute to leaky gut.
Alcohol: Excessive alcohol consumption can damage the gut lining and increase intestinal permeability.

It’s important to note that leaky gut is a complex condition and may have multiple underlying causes. If you’re concerned about leaky gut, it’s a good idea to see a doctor for a proper diagnosis.

There are several ways to improve gut health and support a healthy gut microbiome. Some ways to improve gut health include:

Eating a healthy diet: Eating a diet rich in whole foods, including plenty of fruits, vegetables, whole grains, lean protein, and healthy fats can help support a healthy gut microbiome.
Including probiotics and prebiotics: Probiotics are beneficial bacteria that can help support a healthy gut microbiome. Prebiotics are non-digestible fibers that feed the beneficial bacteria in the gut. Including probiotic-rich foods such as yogurt, kefir, sauerkraut, and kimchi, as well as prebiotic-rich foods such as onions, garlic, bananas, and asparagus can help support gut health.
Managing stress: Chronic stress can weaken the immune system and contribute to inflammation in the gut. Finding ways to manage stress, such as through exercise, meditation, or deep breathing can help support gut health.
Avoiding triggers: Certain foods or substances can trigger inflammation in the gut. Identifying and avoiding these triggers can help reduce inflammation and support gut health.
Staying hydrated: Drinking plenty of water can help support digestion and keep the gut lining healthy.

It’s important to note that everyone is different and what works for one person may not work for another. It’s a good idea to work with a healthcare professional to develop a personalized plan for improving gut health.